yukari

Dr. Yukari Manabe

Honorary Associate Professor
Professor of Medicine, International Health, and Molecular Microbiology and Immunology
Dr. Manabe is currently the Associate Director of Global Health Research and Innovation within the Johns Hopkins Center for Global Health, Professor of Medicine, International Health, and Molecular Microbiology and Immunology, and a faculty member of both the Center for Tuberculosis Research and Center for Clinical Global Health Education.

Dr. Manabe is the first Clinical Director of the John G. Bartlett Speciality Practice, a state-of-the-art clinic established at Johns Hopkins in May 2017 for patients with infectious diseases.

From 2007 until 2012, she was the Head of Research at the Infectious Diseases Institute (IDI) in Kampala, Uganda, where she built research infrastructure, improved research regulatory compliance, enlarged the pool of statistical expertise, began a translational research lab to build basic science research, and streamlined scientific research at the IDI which has led to increased academic productivity and formal recognition of the IDI as a Research Center of Excellence. She also consolidated and built the research capacity-building programs which has trained numerous Ugandan masters and Ph.D. students within the country. Her own research is in diagnostic accuracy testing in HIV, TB, sexually transmitted infections, and acute febrile illness. She has also done research in health systems strengthening and implementation science particularly in the area of TB-HIV infection and opportunistic infections.

Dr. Manabe is an author of more than 170 peer-reviewed publications.

Dr. Manabe obtained her undergraduate degree from Yale University and her MD from Columbia University College of Physicians and Surgeons. She joined the Johns Hopkins School of Medicine faculty in 1999 after completing her residency in internal medicine and fellowship in infectious diseases at Johns Hopkins Hospital.

Publications

High Burden of Bloodstream Infections Associated with Antimicrobial Resistance and Mortality in the Neonatal Intensive Care Unit in Pune, India

Post Date:

2020-05-18

Publication:

Clinical Infectious Diseases

Background: Antimicrobial resistance (AMR) is a growing threat to newborns in low and middle-income countries (LMIC). Methods: We performed a prospective cohort study in three tertiary Neonatal Intensive Care Units (NICUs) in Pune, India, to describe the epidemiology of neonatal bloodstream…

A parsimonious host inflammatory biomarker signature predicts incident TB and mortality in advanced HIV

Post Date:

2019-11-25

Publication:

Clinical Infectious Diseases

BACKGROUND: People with advanced HIV (CD4<50) remain at high risk of TB or death despite the initiation of antiretroviral therapy. We aimed to identify immunological profiles that were most predictive of incident TB disease and death. METHODS: The REMEMBER randomized clinical trial enrolled 850…

Users beware! Biological variation in complete blood counts over short time intervals

Post Date:

2019-05-29

Publication:

BMJ Evidence-Based Medicine

New publication in BMJ Evidence-Based Medicine looks at CBC count variations in blood drawn over a short time period

Group mentorship model to enhance the efficiency and productivity of Ph.D. research training in Sub-Saharan Africa

Post Date:

2018-05-04

|

Countries:

Uganda

Publication:

Annals of Global Health

Annals of Global Health : Systems capacity building approach to Ph.D. training allowed strong outputs at a lower cost and with relatively few additional mentors to train independent scientists able to conduct original research and mentor others.

Re: How serious are global health leaders about gender equality?

Post Date:

2018-04-06

Publication:

British Medical Journal

Letter to the Editor: At the 2017 Consortium of Universities for Global Health (CUGH) in Washington, D.C., a panel of female global health leaders (AG, MB, IK, JM, YM) discussed the barriers to female leadership and put forward actionable advice on how to address them.

Vector-borne disease is a common cause of hospitalized febrile illness in India

Post Date:

2018-03-26

|

Clinical Sites:

BJGMC

Publication:

American Journal of Tropical Medicine and Hygiene

Diagnostic strategies adapted for season and age may reduce diagnostic uncertainty and identify causative organisms in treatable, fatal causes of AFI.

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date:

2017-10-23

|

Countries:

India

|

Clinical Sites:

BJGMC

Publication:

AIDS

Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial…

Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date:

2017-04-27

Publication:

Handbook of Tuberculosis

In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and immunological…

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date:

2017-03-27

Publication:

The American Journal of Tropical Medicine and Hygiene

After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda

Post Date:

2015-02-15

|

Countries:

Uganda

Publication:

BMC Infectious Diseases

Background : Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be missed; delays in diagnosis can be fatal. Given the duration for MTB…

Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults

Post Date:

2014-07-01

|

Countries:

South Africa

Uganda

Publication:

Journal of Acquired Immune Deficiency Syndromes

Objective : In settings of high HIV prevalence, tuberculosis control and patient management are hindered by lack of accurate, rapid tuberculosis diagnostic tests that can be performed at point-of-care. The Determine TB LAM Ag (TB LAM) test is a lateral flow immunochromatographic test for…

Optimisation of the Medical Education Partnership Initiative to address African health-care challenges

Post Date:

2014-06-25

|

Countries:

Uganda

Publication:

The Lancet Global Health

The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa.1 MEPI allows African institutions that…

Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/RIF in HIV-infected individuals

Post Date:

2014-06-01

|

Countries:

Uganda

Publication:

AIDS

Background : Xpert MTB/RIF (‘Xpert’) and urinary lipoarabinomannan (LAM) assays offer rapid tuberculosis (TB) diagnosis, but have suboptimal sensitivity when used individually in HIV-positive patients. The yield of these tests used in combination for the diagnosis of active TB among HIV-…

Cost-effectiveness of novel algorithms for rapid diagnosis of tuberculosis in HIV-infected individuals in Uganda

Post Date:

2013-11-28

|

Countries:

Uganda

Publication:

AIDS

Objective : Xpert MTB/RIF (‘Xpert’) and urinary lateral-flow lipoarabinomannan (LF-LAM) assays offer rapid tuberculosis (TB) diagnosis. This study evaluated the cost-effectiveness of novel diagnostic algorithms utilizing combinations of Xpert and LF-LAM for the detection of active TB among…

Cost-utility of lateral-flow urine lipoarabinomannan for tuberculosis diagnosis in HIV-infected African adults

Post Date:

2013-04-15

|

Countries:

South Africa

Uganda

Publication:

International Journal of Tuberculosis and Lung Disease

Setting : In-patient hospitals in South Africa and Uganda. Objective : To evaluate the cost-effectiveness of a lateral-flow urine lipoarabinomannan (LAM) test when added to existing strategies for tuberculosis (TB) diagnosis in human immunodeficiency virus infected adults (…

Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study

Post Date:

2008-05-12

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Countries:

United States

Publication:

BMC Public Health

Background: In the U.S. more than half of incident tuberculosis (TB) cases occur in immigrants. Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting…

U.S. medical resident familiarity with national tuberculosis guidelines

Post Date:

2007-08-02

|

Countries:

United States

Publication:

BMC Infectious Diseases

Background: The ability of medical residents training at U.S. urban medical centers to diagnose and manage tuberculosis cases has important public health implications. We assessed medical resident knowledge about tuberculosis diagnosis and early management based on the American Thoracic Society…

The expanding realm of heterologous immunity: friend or foe?

Post Date:

2006-02-15

Publication:

Cellular Microbiology

Antecedent or current infections can alter the immunopathologic outcome of a subsequent unrelated infection. Immunomodulation by co-infecting pathogens has been referred to as ‘heterologous immunity’ and has been postulated to play a role in host susceptibility to disease, tolerance to organ…

Mycobacterial-induced potentiation of type 1 immune responses and protection against malaria is host-specific

Post Date:

2005-12-15

Publication:

Infection and Immunity

Malaria and tuberculosis are endemic in many regions of the world, and coinfection with the two pathogens is common. In this study, we examined the effects of long- and short-term infection with Mycobacterium tuberculosis on the course of a lethal form of murine malaria in resistant (C57BL/6…

 

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