You are invited to attend:
BME SEMINAR
Hosted by: Dr. Robert Ssekitoleko
PERSONALIZED MEDICINE FOR ALL: DEVELOPING AND TRANSLATING DIAGNOSTICS, TREATMENTS, AND CURES WITH EQUITY
Dr. Umut Gurkan, PhD
Wilbert J. Austin Professor of Engineering
Case Western Reserve University
Mechanical and Aerospace Engineering
Biomedical Engineering
Case Comprehensive Cancer Center
Cleveland, Ohio
umut@case.edu
Tuesday, October 18, 2022, at 12:00 pm – 1:00 pm
Physiology Lecture Theatre (Snacks provided)
Abstract
Personalized medicine for all: developing and translating diagnostics, treatments, and cures with equity
We are entering a new era in diagnosing, preventing, treating, and curing major health problems and diseases with rapid advances in point-of-care diagnostics, novel therapeutics, mRNA vaccines, and genome-editing-based cures. Despite recent successes, a massive gap exists between the universities, companies, clinics, and researchers developing new diagnostics and therapeutics and their availability to the people who need them the most. The unacceptable reality is a geographic and demographic exclusion of specific populations, resource-limited clinics, and low-and middle-income countries in new therapy and diagnostic development and utilization. This is particularly relevant for cell and gene therapies to treat human immunodeficiency virus infection and hemoglobinopathies, such as sickle cell disease, which are global health crises impacting tens of millions of people, primarily in resource-constrained regions. Millions of babies are born with severe hemoglobin mutations, such as sickle cell anemia and beta-thalassemia. 99% of people living with severe hemoglobin disorders reside in low- and middle-income countries. In these regions, preventable blood disorders go primarily undiagnosed and untreated, which leads to high mortality rates in children under five. My group works on gaining a fundamental understanding of hemoglobin, red blood cells, blood rheology, blood cell biology, vascular biology, and human microcirculation. Our research has led to new biomedical microtechnologies that improve access to timely diagnosis and personalized management of existing and emerging treatments. In this talk, I will present our use-driven and need-oriented adaptive engineering approach with roots in fundamental design thinking. I will describe an innovation-enabled, accessible, personalized medicine approach for underserved populations. I will share real-world experience from clinical studies conducted in the US and overseas, which led to new point-of-care diagnostic technologies (Gazelleâ Hb Variant, Hemex Health, Inc.) in use in over 44 countries worldwide.
Speaker’s bio sketch
Umut A. Gurkan, Ph.D., is the Wilbert J. Austin Professor of Engineering with tenure at Case Western Reserve University. Dr. Gurkan holds BS degrees in Chemical Engineering and Mechanical Engineering from the Middle East Technical University in Turkey and a Ph.D. degree in Biomedical Engineering from Purdue University. He completed his postdoctoral training at Harvard Medical School and Harvard-MIT Health Sciences and Technology. Dr. Gurkan’s research is on global equitable access to diagnostics and personalized health. Dr. Gurkan is a leader in the efficient translation of microfluidics and point-of-care diagnostics for blood disorders and cancer. He has led international clinical studies on sickle cell disease research in the United States, Africa, Southeast Asia, and India. Dr. Gurkan has authored over 90 peer-reviewed journal articles. His research has been supported by the NSF, NIH, DoD, non-profit organizations, and several industrial partners. Dr. Gurkan’s inventions have led to 12 issued US patents and four successful biotechnology companies to date with products in global markets. Dr. Gurkan’s innovations won numerous awards, including USPTO Patents for Humanity recognition and USFDA Breakthrough Device Designation. His honors include National Science Foundation CAREER Award, the American Society for Engineering Education Curtis W. McGraw Research Award Finalist, Translational Research Featured New Investigator Award, the Biomedical Engineering Society Rising Star Award, MIT Technology Review Innovator under 35 Award, the Doris Duke Innovations in Clinical Research Award, and NHLBI featured him in Today’s Faces of Sickle Cell Disease. Dr. Gurkan is a member of the Global Gene Therapy Initiative, American Society of Mechanical Engineers, Biomedical Engineering Society, and American Society of Hematology. Dr. Gurkan is a Senior Member of the National Academy of Inventors (NAI), a member of the New Voices in Science, Engineering and Medicine Program by the National Academies of Sciences, Engineering, and Medicine (NASEM), and a fellow of the American Institute for Medical and Biological Engineering (AIMBE).