Dr. Musa Sekikubo, MBChB, MMED, PhD has directed health service delivery at health sub-district and hospital facilities in Mukono district, conducted research at Makerere University and currently co-ordinate undergraduate and post graduate courses at the College of Health Sciences in the Department of Obstetrics and Gynaecology. He has actively participated in establishing collaborations between the Department of Obstetrics and Gynaecology and Yale University. Additionally, as a senior lecturer, he supervise masters and doctoral student research.

Research experience:

1. OPP1189053       Kirsty Le Doare (PI)       15/10/2018 – 04/30/2020

This was baseline survey to established the sero-epidemiology group B Streptococcus carriage among pregnant women in Mulago hospital and investigate the sero-correlates of protection. I was the local Principal Investigator of this study

Funding Agency: Bill and Melinda Gates Foundation

Award Amount: USD 1,089,482

2. RIA2018V-2304 Kirsty Le Doare     01/06/19 – 01/06/24 

This is a five-component survey that includes establishing baseline characteristics of maternal and neonatal outcomes in Kawempe National Referral Hospital in preparation for maternal vaccine trials to prevent invasive Group B Streptococcus disease in newborn babies. Am the local Principal Investigator and supervisor of doctoral student.

Funding Agency: EDCTP

Award Amount: USD 2,714,509 

3. Co-Investigator MTN-042B study
4. Bill and Melinda Gates Foundation Musa Sekikubo (Local PI)                  2019-2020

Sero-epidemiology of maternally-derived antibodies against group B Streptococcus (GBS) in Mulago Hospital Uganda

1. D43TW010132                       Nelson Sewankambo (PI)       09/08/17-09/07/19

Nurture: Research Training and Mentoring Program For Career Development Of Faculty At Makerere University College Of Health Science

The goal of this proposal is to develop a sustainable culture of supporting research training and mentoring for career development of upcoming faculty in an environment at MakCHS that fosters continuous development and retention of independent researchers..

Role: Am a recipient supported to undertake research on Post-Caesarean wound infection: Incidence, causative organisms and antimicrobial susceptibility pattern. The goal of my study is to identify the most common causative organisms of post-caesarean wound infection in Uganda and their antimicrobial susceptibility pattern. This will inform policy on the most effective antimicrobial agents to use in prevention and treatment of surgical wound infections.

Completed Research Support

Martha Piper Research Fund              Gina Ogilvie (PI)                                02/22/09-08/30/17

Advances in screening and prevention of reproductive cancers (ASPIRE).

The goal of the project was to evaluate alternative cervical cancer screening modalities that would rapidly scale up service provision in Uganda. Alternative modalities to Pap smear included HPV testing, see and treat strategy after visual inspection with acetic acid and integrating cervical cancer screening into ongoing programs like ART clinics.

Role: Co-Investigator

PERSONAL ATTRIBUTES:

I desire to make the working conducive to everyone.

Publications:

1: Bayigga L, Kateete DP, Anderson DJ, Sekikubo M, Nakanjako D. Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and

prevention. Am J Obstet Gynecol. 2019 Feb;220(2):155-166. doi:10.1016/j.ajog.2018.10.014. Epub 2018 Oct 12. PubMed PMID: 30321529.

2: Moses E, Pedersen HN, Wagner EC, Sekikubo M, Money DM, Ogilvie GS, Mitchell-Foster SM. Understanding Men’s Perceptions of Human Papillomavirus and

Cervical Cancer Screening in Kampala, Uganda. J Glob Oncol. 2018 Sep;4:1-9. doi:10.1200/JGO.17.00106. PubMed PMID: 30241236; PubMed Central PMCID: PMC6223419.

3: Mezei AK, Pedersen HN, Sy S, Regan C, Mitchell-Foster SM, Byamugisha J, Sekikubo M, Armstrong H, Rawat A, Singer J, Ogilvie GS, Kim JJ, Campos NG. Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial. BMJ Open. 2018 Jun 12;8(6):e020484. doi: 10.1136/bmjopen-2017-020484. PubMed PMID: 29895648; PubMed Central PMCID: PMC6009460.

4: Sekikubo M, Hedman K, Mirembe F, Brauner A. Antibiotic Overconsumption in Pregnant Women With Urinary Tract Symptoms in Uganda. Clin Infect Dis. 2017 Aug 15;65(4):544-550. doi: 10.1093/cid/cix356. PubMed PMID: 29017265.

5: Mezei AK, Armstrong HL, Pedersen HN, Campos NG, Mitchell SM, Sekikubo M, Byamugisha JK, Kim JJ, Bryan S, Ogilvie GS. Cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: A systematic review. Int J Cancer. 2017 Aug 1;141(3):437-446. doi: 10.1002/ijc.30695. Epub 2017 Apr 3. Review. PubMed PMID: 28297074.

6: Mitchell SM, Pedersen HN, Eng Stime E, Sekikubo M, Moses E, Mwesigwa D, Biryabarema C, Christilaw J, Byamugisha JK, Money DM, Ogilvie GS. Self-collection based HPV testing for cervical cancer screening among women living with HIV in Uganda: a descriptive analysis of knowledge, intentions to screen and factors associated with HPV positivity. BMC Womens Health. 2017 Jan 13;17(1):4. doi: 10.1186/s12905-016-0360-0. PubMed PMID: 28086933; PubMed Central PMCID: PMC5237237.

7: Sirima SB, Mordmüller B, Milligan P, Ngoa UA, Kironde F, Atuguba F, Tiono AB, Issifou S, Kaddumukasa M, Bangre O, Flach C, Christiansen M, Bang P, Chilengi R, Jepsen S, Kremsner PG, Theisen M; GMZ2 Trial Study Group. A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children. Vaccine. 2016 Aug 31;34(38):4536-4542. doi: 10.1016/j.vaccine.2016.07.041. Epub 2016 Jul 28. PubMed PMID: 27477844.

8: Mitchell SM, Pedersen HN, Sekikubo M, Biryabarema C, Byamugisha JJ, Mwesigwa D, Steinberg M, Money DM, Ogilvie GS. Strategies for Community Education Prior to Clinical Trial Recruitment for a Cervical Cancer Screening Intervention in Uganda. Front Oncol. 2016 Apr 13;6:90. doi: 10.3389/fonc.2016.00090. eCollection PubMed PMID: 27148482; PubMed Central PMCID: PMC4829601.

9: Moses E, Pedersen HN, Mitchell SM, Sekikubo M, Mwesigwa D, Singer J, Biryabarema C, Byamugisha JK, Money DM, Ogilvie GS. Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomized controlled trial. Trop Med Int Health. 2015 Oct;20(10):1355-67. doi: 10.1111/tmi.12549. Epub 2015 Jun 28. PubMed PMID: 26031572.

10: Ramos NL, Sekikubo M, Kironde F, Mirembe F, Sääf M, Brauner A. The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy. Clin Microbiol Infect. 2015 May;21(5):482.e1-7. doi: 10.1016/j.cmi.2014.12.010. Epub 2014 Dec 26. PubMed PMID: 25640157.

11: Dlamini LD, Sekikubo M, Tumukunde J, Kojjo C, Ocen D, Wabule A, Kwizera A. Antibiotic prophylaxis for caesarean section at a Ugandan hospital: a randomized clinical trial evaluating the effect of administration time on the incidence of postoperative infections. BMC Pregnancy Childbirth. 2015 Apr 12;15:91. doi: 10.1186/s12884-015-0514-3. PubMed PMID: 25884350; PubMed Central PMCID: PMC4417223.

12: Kaddumukasa M, Buwembo W, Sekikubo M, Naiwumbwe H, Namusoke F, Kiwuwa S, Oketch B, Noor R, Chilengi R, Mworozi E, Kironde F. Malariometric indices from Iganga, Uganda: baseline characterization in preparation of GMZ2 vaccine trial. BMC Res Notes. 2014 Nov 8;7:793. doi: 10.1186/1756-0500-7-793. PubMed PMID: 25380673; PubMed Central PMCID: PMC4232662.

13: Teng FF, Mitchell SM, Sekikubo M, Biryabarema C, Byamugisha JK, Steinberg M, Money DM, Ogilvie GS. Understanding the role of embarrassment in gynaecological screening: a qualitative study from the ASPIRE cervical cancer screening project in Uganda. BMJ Open. 2014 Apr 11;4(4):e004783. doi: 10.1136/bmjopen-2014-004783. PubMed PMID: 24727360; PubMed Central PMCID: PMC3987737.

14: Mitchell SM, Sekikubo M, Biryabarema C, Byamugisha JJ, Steinberg M, Jeronimo J, Money DM, Christilaw J, Ogilvie GS. Factors associated with high-risk HPV positivity in a low-resource setting in sub-Saharan Africa. Am J Obstet Gynecol. 2014 Jan;210(1):81.e1-7. doi: 10.1016/j.ajog.2013.08.038. Epub 2013 Aug 30. PubMed PMID: 23999419.

15: Ogilvie GS, Mitchell S, Sekikubo M, Biryabarema C, Byamugisha J, Jeronimo J, Miller D, Steinberg M, Money DM. Results of a community-based cervical cancer screening pilot project using human papillomavirus self-sampling in Kampala, Uganda. Int J Gynaecol Obstet. 2013 Aug;122(2):118-23. doi: 10.1016/j.ijgo.2013.03.019. Epub 2013 Jun 2. PubMed PMID: 23731506.

16: Ramos NL, Sekikubo M, Dzung DT, Kosnopfel C, Kironde F, Mirembe F, Brauner A. Uropathogenic Escherichia coli isolates from pregnant women in different countries. J Clin Microbiol. 2012 Nov;50(11):3569-74. doi: 10.1128/JCM.01647-12. Epub 2012 Aug 22. PubMed PMID: 22915606; PubMed Central PMCID: PMC3486199.

17: Atuhairwe S, Busingye RB, Sekikubo M, Nakimuli A, Mutyaba T. Urologic complications among women with advanced cervical cancer at a tertiary referral hospital in Uganda. Int J Gynaecol Obstet. 2011 Dec;115(3):282-4. doi: 10.1016/j.ijgo.2011.07.021. Epub 2011 Sep 19. PubMed PMID: 21937039.

18: Mitchell S, Ogilvie G, Steinberg M, Sekikubo M, Biryabarema C, Money D. Assessing women’s willingness to collect their own cervical samples for HPV testing as part of the ASPIRE cervical cancer screening project in Uganda. Int J Gynaecol Obstet. 2011 Aug;114(2):111-5. doi: 10.1016/j.ijgo.2011.01.028. Epub 2011 Jun 12. PubMed PMID: 21669428.

19: Fazliana M, Ramos NL, Lüthje P, Sekikubo M, Holm A, Wan Nazaimoon WM, Brauner A. Labisia pumila var. alata reduces bacterial load by inducing uroepithelial

cell apoptosis. J Ethnopharmacol. 2011 Jun 14;136(1):111-6. doi: 10.1016/j.jep.2011.04.018. Epub 2011 Apr 15. PubMed PMID: 21524700.